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Medicinal chemistry :

by King, Frank D.
Published by : Royal Society of Chemistry, (Cambridge :) Physical details: xxi, 313 p. : ill. ; 24 cm Year: 1994
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Books Books 615.19 K521 (Browse shelf) Available MEU-112381

"Lectures presented at the 7th RSC Medicinal Chemistry School held between 28th June and 3rd July in 1993 at the University of Kent, Canterbury, UK"--Pref

Includes bibliographical references and subject index

An introduction to drug-receptor interactions / Barry Hunt -- Signal transduction and second messengers / Trevor J. Franklin -- Enzyme inhibitors / David A. Roberts -- The biological evaluation of new compounds / Robert A. Coleman -- Pharmacokinetics / Robert M.J. Ings -- Drug metabolism / Colin Vose -- Physicochemical properties and drug design / Nigel P. Gensmantel -- Quantitative structure-activity relationships / Andrew M. Davis -- Considerations for the use of computational chemistry techniques by medicinal chemists / Mike M. Hann -- 'Patent medicine' / Bill Tyrrell -- Molecular biology : a new route to drug discovery / Janet E. Carey -- Devising a research strategy / Colin W. Greengrass -- Past approaches to discovering new drugs as medicines / C. Robin Ganellin -- Bioisosteres, conformational restriction and pro-drugs : approaches to lead optimisation, case history : an example of a conformational restriction approach / Frank D. King -- The design and synthesis of selective protein kinase C inhibitors / Christopher H. Hill -- Discovery of 1069C : a novel synthetic antitumour agent with low cross-resistance potential / Simon T. Hodgson -- The design and biological properties of 'dipeptoid' antagonists / David C. Horwell -- Migraine therapy : from serotonin to sumatriptan / Peter C. North -- Drug development / Jane Ormerod

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